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Refla 24 Tablet 1 Strip
Refla 24
- Hepatic impairment: Monitor and adjust dose to the lowest effective level
- Renal impairment and the elderly: No additional precautions beyond standard glucocorticoid guidelines
- Pregnancy: Crosses the placenta. Prolonged use may cause intrauterine growth restriction. Use only if the benefits outweigh the risks.
- Breastfeeding: Excreted in breast milk. Doses ≤50 mg/day are unlikely to affect the infant significantly. Monitor if using higher doses.
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✅ Description:
Refla is prescribed for a wide range of inflammatory, autoimmune, and immunological conditions, including:
- Severe allergic reactions: Anaphylaxis, asthma, and hypersensitivity disorders
- Rheumatologic diseases: Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica
- Systemic autoimmune diseases: Systemic lupus erythematosus, dermatomyositis, sarcoidosis, polyarteritis nodosa
- Severe dermatologic conditions: Pemphigus, bullous pemphigoid, pyoderma gangrenosum
- Renal and cardiac conditions: Minimal change nephrotic syndrome, acute interstitial nephritis, rheumatic carditis
- Gastrointestinal diseases: Ulcerative colitis, Crohn’s disease
- Ophthalmic issues: Uveitis, optic neuritis
- Hematologic disorders: Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura
- Malignancies: Acute lymphatic leukemia, lymphoma, multiple myeloma
- Post-transplant immune suppression
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Indications:
Deflazacort, a synthetic glucocorticoid, suppresses inflammation by inhibiting the Phospholipase A2 enzyme, reducing prostaglandin synthesis. It also decreases the release of immune mediators, providing immunosuppressive benefits in autoimmune and inflammatory diseases.
✔️ Possible Side Effects
- Gastrointestinal: Nausea, indigestion
- Musculoskeletal: Osteoporosis, myopathy
- Endocrine/Metabolic: Adrenal suppression, hyperglycemia
- Neuropsychiatric: Mood changes, psychosis
- Skin: Acne, thinning, striae, delayed wound healing
- Others: Thromboembolism, infection risk, eye complications (e.g., cataracts, glaucoma)
✔️ Dosage & Administration
Adults:
Acute conditions: Up to 120 mg/day initially
Maintenance dose: 3–18 mg/day
Rheumatoid arthritis: 3–18 mg/day based on response
Acute asthma attacks: 48–72 mg/day, tapered after control
Chronic asthma: Titrate to the lowest effective dose
Dosage equivalence: 6 mg Deflazacort ≈ 5 mg Prednisone/Prednisolone
Children:
General pediatric dosing: 0.25–1.5 mg/kg/day
Juvenile arthritis: 0.25–1.0 mg/kg/day
Nephrotic syndrome: Start with 1.5 mg/kg/day, taper based on response
Asthma: 0.25–1.0 mg/kg every other day
Withdrawal:
Tapering is essential for those using >9 mg/day for over 3 weeks. Reduce dose gradually to prevent adrenal insufficiency and disease flare.
✔️ Drug Interactions
- Enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin) may lower Deflazacort levels—dose adjustment may be needed
- Enzyme inhibitors (e.g., ketoconazole) may increase drug levels—consider dose reduction
✔️ Contraindications
- Hypersensitivity to Deflazacort or excipients
- Recent or ongoing live virus vaccination
✔️ Monitor patients closely if they have:
- Cardiovascular disease, hypertension, or thromboembolic risks
- GI disorders: Ulcers, diverticulitis, or recent GI surgery
- Endocrine/metabolic risks: Diabetes, hypothyroidism, osteoporosis
- Neurologic or psychiatric history: Epilepsy, emotional instability
- Eye diseases: Especially ocular herpes simplex
- Liver impairment: May increase drug levels—dose adjustment may be necessary
✔️ Storage Conditions
Store at temperatures below 25°C, in a dry place, away from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
